Twentyone Hotel

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy - Near Vatican City
4.0 1904 reviews

Featuring a restaurant and a barber shop, Twentyone Hotel Rome is located just 6 minutes' stroll from Piazza Cavour. The 4-star hotel lies in the Vaticano Prati district, 1.1 miles from such cultural sights as the aqueduct-fed rococo Trevi Fountain.

Location

Situated approximately 25 minutes by foot from Basilica of St. Mary of the Angels and the Martyrs, the Rome hotel also gives access to such sports venues as Stadio Olimpico Stadium, which is approximately a 10-minute drive away. The Twentyone Rome also lies 0.5 miles from the large urban square "Piazza del Popolo" and 1.5 miles from Roman Forum. Entertainment options in the area feature the night Raspoutine Rome Club within easy reach of the property. Villa Borghese/Washington bus station can be found around 10 minutes' stroll away, and the closest subway station Lepanto is a mere 5 minutes by foot from this Rome hotel.

Rooms

The Twentyone features 88 rooms equipped with a flat-screen TV with satellite channels as well as a mini bar fridge, tea and coffee-making facilities. Private bathrooms also include dressing gowns and slippers. Guests staying in air-conditioned rooms can adore the views of the pool.

Food & Drinks

The neighborhood features restaurants, including Route 66, which is in close proximity to Twentyone Hotel.

Why choose Twentyone Hotel Rome

Select room
  • Strategic location near attractions

  • Modern rooms with elegant decor

  • On-site Bistrò 21 restaurant

  • Complimentary buffet breakfast included

Main amenities

  • Wi-Fi

  • 24-hour services

  • Express check-in/ -out

  • Fitness/Gym

  • On-site Dining

  • No Smoking

  • Child-friendly

  • Wheelchair access

  • Breakfast

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • 24-hour services
  • Express check-in/ -out
  • Fitness/Gym
  • On-site Dining
  • No Smoking
  • Child-friendly
  • Wheelchair access
  • Breakfast
  • Air conditioning
  • No pets allowed
1/31

Internet

  • Wi-Fi

Parking options

  • Parking

Shuttle

  • Paid airport shuttle

Activities

  • Fitness centre

Property services

  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Security
  • Luggage storage
  • Barber shop
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining options

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business facilities

  • Fax/Photocopying

For kids

  • Cots
  • Children's buffet

Recreation

  • Garden area
  • Leisure/ TV room

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Toilet for disabled
  • Bathroom for disabled

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries
  • Sink

Devices

  • Flat-screen TV
  • AM/FM alarm clock

Design

  • Carpeted floor

General facilities

  • Non-smoking rooms
  • Allergy-free rooms
  • Lift
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Pets

  • No pets allowed

Important information

Check-in:
from 15:00 until 23:59
Check-out:
from 07:00 until 11:00
License number058091-ALB-00313,IT058091A1GZ5MCI9I
  • Children and extra beds
  • There are no cribs provided in a room.

Enter dates to see availability

From USD 82 per night
Check-in 19 Mar 2026
Check-out 20 Mar 2026
Guests 2 guests

Adults:

2

Children:

0

Rooms

Photos of Twentyone Hotel Rome

Location of Twentyone Hotel Rome

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy

 -  Near Vatican City
Attractions
Great restaurants
Transportation

Places nearby

    Guest reviews of Twentyone Hotel Rome

    Write a review

    When did you travel?

    Your rating point

    Very bad
    Excellent

    Your details

    Where are you from?
    Thank you! Thank you for taking the time to share your experience. Your review will be published shortly.

    Review has not been sent.

    Please try again.

    Popular hotels in Rome

    Find your perfect hotel stay today

    Popular hotels all over the world

    Find your perfect hotel stay today

    Currency
    • USD U.S. dollar
    • EUR Euro
    • GBP Pound sterling
    • AUD Australian dollar
    • CAD Canadian dollar
    • BRL Brazilian real
    • BGN Bulgarian lev
    • CNY Chinese yuan
    • CZK Czech koruna
    • DKK Danish krone
    • HKD Hong Kong dollar
    • ILS Israeli new sheqel
    • JPY Japanese yen
    • MYR Malaysian ringgit
    • NZD New Zealand dollar
    • NOK Norwegian krone
    • PLN Polish zloty
    • RON Romanian leu
    • RUB Russian ruble
    • SAR Saudi riyal
    • SGD Singapore dollar
    • ZAR South African rand
    • KRW South Korean won
    • SEK Swedish krona
    • CHF Swiss franc
    • TRY Turkish lira
    • UAH Ukrainian hryvnia
    • THB Thai baht
    • ARS Argentina, Peso
    Select language
    100% Verified Reviews
    Enter dates to see availability
    From USD 82 per night
    Check-in 19 Mar 2026
    Check-out 20 Mar 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    Check-in & out
    19 Mar 2026
    20 Mar 2026
    Guests
    2 guests
    Contact Us
    Twentyone Hotel
    Your details
    Subject:
    Message:
    Your message has been sent
    Your message was not delivered

    Details:

    Via Cola Di Rienzo 23, Rome, Italy

    Important information
    Twentyone Hotel
    Check-in:
    from 15:00 until 23:59
    Check-out:
    from 07:00 until 11:00
    License number058091-ALB-00313,IT058091A1GZ5MCI9I
    • Children and extra beds
    • There are no cribs provided in a room.